Botulinum toxins: pharmacology and its current therapeutic evidence for use.
Neurol India
; 2003 Dec; 51(4): 455-60
Article
in En
| IMSEAR
| ID: sea-121826
ABSTRACT
Botulinum toxins are, as a group, among the most potent neuromuscular toxins known, yet they are clinically useful in the management of conditions associated with muscular and glandular over-activity. Botulinum toxins act by preventing release of acetylcholine into the neuromuscular junction. While botulinum toxin type A is commonly available, different manufacturers produce specific products, which are not directly interchangeable and should not be considered as generically equivalent formulations. Type B is also available in the market. Each formulation of botulinum toxin is unique with distinct dosing, efficacy and safety profiles for each use to which it is applied. Botulinum toxin type A is the treatment of choice based on its depth of evidence in dystonias and most other conditions. Botulinum toxin type A is established as useful in the management of spasticity, tremors, headache prophylaxis and several other neurological conditions. Active research is underway to determine the parameters for which the type B toxin can be used in these conditions, as covered in this review. Botulinum toxin use has spread to several fields of medicine.
Full text:
1
Index:
IMSEAR
Main subject:
Tremor
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Botulinum Toxins
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Humans
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Anti-Dyskinesia Agents
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Dystonia
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India
Country/Region as subject:
Asia
Language:
En
Journal:
Neurol India
Year:
2003
Type:
Article