Theoretical studies on the pyridoxal-5'-phosphate dependent enzyme dopa decarboxylase: Effect of Thr 246 residue on the co-factor-enzyme binding and reaction mechanism.

Chakrabarty, Kuheli; Gupta, Sampad Narayan; Das, Gourab Kanti; Roy, Sukhendu

Chakrabarty, Kuheli; Gupta, Sampad Narayan; Das, Gourab Kanti; Roy, Sukhendu.

Indian J Biochem Biophys ; 2012 Jun; 49(3): 155-164

Article in En | IMSEAR | ID: sea-140231

Subject(s)

Dopa Decarboxylase/chemistry; Dopa Decarboxylase/metabolism; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Pyridoxal Phosphate/chemistry; Pyridoxal Phosphate/metabolism; Structure-Activity Relationship; Threonine/chemistry; Threonine/metabolism

Key words

Enzyme; Molecular dynamics; Quantum mechanics; Density functional theory; Pyridoxal-5'-phosphate; Carbidopa; Decarboxylase; Aldimine

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Full text: 1 Index: IMSEAR Main subject: Protein Conformation / Pyridoxal Phosphate / Structure-Activity Relationship / Threonine / Models, Molecular / Dopa Decarboxylase / Molecular Dynamics Simulation Type of study: Prognostic_studies Language: En Journal: Indian J Biochem Biophys Year: 2012 Type: Article

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