Prophylactic metoclopramide administered immediately after the induction of anesthesia has no effect on the incidence of postoperative emesis after strabismus surgery.
Indian Pediatr
;
1998 Mar; 35(3): 237-41
Article
in English
| IMSEAR
| ID: sea-14112
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of metoclopramide (0.25 mg/kg) administered IV immediately after induction of general anesthesia for the prevention of postoperative emesis in children undergoing, elective strabismus surgery.DESIGN:
Double blind, randomized.SETTING:
Operation-theater. SUBJECTS ANDINTERVENTIONS:
Seventy six non premedicated children of ASA class 1 and 2 were randomly allocated to receive either normal saline or metoclopramide immediately after the induction of general anesthesia. All children received a standardized similar anesthetic technique. Postoperative analgesia consisted of oral indomethacin.RESULTS:
The incidence of postoperative emesis in the metoclopramide group was 60% versus 71% in a placebo group (p < 0.05). The incidence of severe emesis (2 or > 2 vomiting) was similar in the placebo group (34.20%) and metoclopramide group (21.05%). There were no adverse reactions like excessive sedation, extrapyramidal signs and hemodynamic depression in either placebo or metoclopramide group.CONCLUSIONS:
Metoclopramide in a dose of 0.25 mg/kg administered intravenously prior to manipulation of eyeball is devoid of the effects but is not effective in preventing postoperative emesis in children undergoing strabismus surgery.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Premedication
/
Time Factors
/
Vomiting
/
Severity of Illness Index
/
Female
/
Humans
/
Male
/
Drug Administration Schedule
/
Chi-Square Distribution
/
Child
Type of study:
Controlled clinical trial
/
Incidence study
/
Prognostic study
Language:
English
Journal:
Indian Pediatr
Year:
1998
Type:
Article
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