Histological and immunohistochemical features in fatal acute fulminant hepatitis E.
Indian J Pathol Microbiol
; 2012 Jan-Mar 55(1): 22-27
Article
in En
| IMSEAR
| ID: sea-142170
ABSTRACT
Background:
Hepatitis E is being increasingly recognized as an emerging infection in developed countries. Data on histological findings and nature of inflammatory cell infiltrate in liver in this disease are quite sparse.Aims:
This study was planned to study the histological features and the type of inflammatory infiltrate in liver biopsies of patients with acute fulminant hepatitis E. Materials andMethods:
We retrieved postmortem liver biopsies of 11 Indian patients with fulminant hepatitis E, and compared these with biopsies from seven patients with fulminant hepatitis B.Results:
Biopsies from acute fulminant hepatitis E showed varying degrees of hepatocyte necrosis, mixed portal and lobular inflammation, accompanied by bile ductular proliferation, lymphocytic cholangitis, Kupffer cell prominence, cholestasis, apoptotic bodies, pseudo-rosette formation, steatosis, and presence of plasma cells in portal tracts. Interface hepatitis was more frequent in acute hepatitis B than in acute hepatitis E (100% vs 20%; P<0.05). These findings differ from those reported in cases with autochthonous hepatitis E in Europe. On immunohistochemistry, lymphocyte infiltrate consisted predominantly of CD3 + T cells in both hepatitis E and hepatitis B; these cells contained a predominant cytotoxic (CD8 + ) cell subpopulation in 81.8% of cases with hepatitis E and in 50% of cases with hepatitis B.Conclusion:
Our findings suggest that histological changes in HEV infection may vary with geographical location because of prevalent HEV genotypes, and that CD8 + lymphocytes play a role in HEV-induced liver injury.Key words
Full text:
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Index:
IMSEAR
Main subject:
Biopsy
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Female
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Humans
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Male
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Immunohistochemistry
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Child
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Adolescent
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Hepatitis E
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CD3 Complex
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CD8-Positive T-Lymphocytes
Language:
En
Journal:
Indian J Pathol Microbiol
Year:
2012
Type:
Article