Viral markers in patients with hemophagocytosis: A prospective study in a tertiary care hospital.
Indian J Pathol Microbiol
;
2012 Apr-Jun 55(2): 215-217
Article
in English
| IMSEAR
| ID: sea-142225
ABSTRACT
Background:
Hemophagocytic syndrome (HPS) is a rare clinicopathological condition characterized by the activation of macrophages with prominent hemophagocytosis in bone marrow and other reticulo-endothelial systems. HPS can be familial or secondary to infections including viruses.Aim:
To study the viral markers in patients with HPS. Materials andMethods:
Serum samples of patients with HPS and control group were screened for anti EBV VCA IgM, and IgG, anti-Parvo B19 IgM, and anti-CMV IgM antibodies using commercially available ELISA kits and CMV and ParvoB19 DNA by polymerase chain reaction (PCR). Results andDiscussion:
The present prospective study reports the profile of viral markers in HPS cases from north India. Among the 14 HPS cases 43% (6/14) were positive for at least one viral marker tested, of which EBV was found to be the most prevalent (3/6 50%) followed by parvovirus B19(2/6 33%) and cytomegalovirus (1/6 17%). Mortality was noted in 33% of virus associated HPS patients. Our study highlights the higher association of Epstein-Barr virus (EBV) with HPS as compared to other viruses along with higher rate of mortality in both parvovirus B 19 and EBV associated HPS.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Male
/
Virus Diseases
/
DNA, Viral
/
Immunoglobulin G
/
Immunoglobulin M
/
Enzyme-Linked Immunosorbent Assay
/
Biomarkers
/
Child
/
Polymerase Chain Reaction
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2012
Type:
Article
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