Pheochromocytoma in children and adolescents.
Indian J Pediatr
; 2009 Nov; 76(11): 1151-1153
Article
in En
| IMSEAR
| ID: sea-142427
ABSTRACT
Eleven subjects aged <20 yr with histologically proven pheochromocytoma between 1987 and 2006 were analyzed. Family history was present in 18%. In 2 patients, pheochromocytoma was part of VHL and in one it was associated with MEN 2. Twenty four hour urine VMA level was elevated in 100% and metanephrine level in 73%. CT/ MRI were showing the tumor in all. Prazosin extended release tablets (maximum 30 mg/day) were used in 73% and doxazosin (maximum 12 mg/ day) in 27%. Intraoperative BP fluctuations were seen in 27%. All were biochemically cured after surgery. Preoperative á blockade with extended release prazosin and doxazosin were effective in controlling perioperative BP fluctuations. Hence these drugs can be used in children and adolescents without fear of postoperative hypotension.
Key words
Full text:
1
Index:
IMSEAR
Main subject:
Pheochromocytoma
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Female
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Humans
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Male
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Prazosin
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Child
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Adolescent
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Treatment Outcome
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Doxazosin
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Adrenal Gland Neoplasms
Language:
En
Journal:
Indian J Pediatr
Year:
2009
Type:
Article