Indian studies on genetic polymorphisms and cancer risk.
Indian J Cancer
; 2012 Jan-Mar; 49(1): 144-162
Article
in En
| IMSEAR
| ID: sea-144565
ABSTRACT
Genetic influences on cancer development have been extensively investigated during the last decade following publication of human genome sequence. The present review summarizes case-control studies on genetic polymorphisms and cancer risk in Indians. It is observed that the most commonly studied genes in the Indian population included members of phase I and phase II metabolic enzymes. Other than these genes, genetic polymorphisms for cell cycle and apoptosis-related factors, DNA repair enzymes, immune response elements, growth factors, folate metabolizing enzymes, vitamin/hormone receptors, etc., were investigated. Several studies also evidenced a stronger risk for combined genotypes rather than a single polymorphism. Gene-environment interaction was also found to be a determining factor for cancer development in some experiments. Data for single polymorphism and single cancer type, however, was insufficient to validate an association. It appears that much more experiments involving larger sample size, cross-tabulating genetic polymorphisms and environmental factors are required in order to identify genetic markers for different cancers in Indian populations.
Key words
Full text:
1
Index:
IMSEAR
Main subject:
Polymorphism, Genetic
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Humans
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Genes, MHC Class II
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Cell Cycle Proteins
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Intercellular Signaling Peptides and Proteins
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DNA Repair Enzymes
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Metabolic Detoxication, Phase I
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Metabolic Detoxication, Phase II
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Genetic Association Studies
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India
Type of study:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Country/Region as subject:
Asia
Language:
En
Journal:
Indian J Cancer
Year:
2012
Type:
Article