Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid.
Indian J Exp Biol
;
2011 Dec; 49(12): 904-908
Article
in English
| IMSEAR
| ID: sea-145207
ABSTRACT
Platelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3X10-3Μ concentration completely inhibited platelet aggregation, decreased thromboxane B2 levels, and inhibited the expression of platelet membranic receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells ratios 12.51, 251 and 501 respectively. The results suggest the role of ascorbic acid in increasing the susceptibility of tumor cells to NKC; the ascorbic acid could be used as part of a multidrug therapy to treat diseases which up to now have been treated only through chemotherapy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Indian J Exp Biol
Year:
2011
Type:
Article
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