The effect of clofibrate with phototherapy in late pre-term newborns with non-hemolytic jaundice.
Indian J Med Sci
; 2009 May; 63(5) 174-179
Article
in En
| IMSEAR
| ID: sea-145404
ABSTRACT
Background:
Despite an understanding of the enzymatic pathways leading to bilirubin production and degradation, very few pharmacologic interventions are utilized and the mainstay of treatment remains phototherapy.Aims:
To evaluate the efficacy of clofibrate in reducing total serum bilirubin levels in late pre-term neonates with non-hemolytic jaundice. Design andSetting:
Double-blind, placebo-controlled, randomized trial; tertiary level neonatal unit. Materials andMethods:
A randomized controlled study was carried out in the neonatal ward of Children's Hospital, Tabriz, Iran, over a 1-year period. Sixty-eight healthy late pre-term infants readmitted with non-hemolytic hyperbilirubinemia were randomized to receive phototherapy and clofibrate (n= 35) or phototherapy and placebo (n= 33). Statistical Analysis Used Chi-square test and independent sample 't' test.Results:
There were no significant differences in the weight, gender, modes of delivery and age of neonates between the two groups. Similarly the mean total serum bilirubin (TSB) level at the time of admission was not significantly different between the two groups [mean± SD 19.72 ± 1.79 (95% confidence interval 19.12-20.54 mg/dL) vs. 20.05 ± 2.82 (95% confidence interval, 19.54-22.04 mg/dL), P= 0.57]. The mean TSB 48 hours after phototherapy [mean± SD 8.06± 1.34 (95% confidence interval 7.94-10.18 mg/dL) vs.10.94 ± 2.87 (95% confidence interval 9.92-12.16 mg/dL), P= 0.02] and the mean duration of phototherapy [mean± SD 64.32 ± 12.48 (95% confidence interval 60-81.6 hours) vs. 87.84 ± 29.76 (95% confidence interval 79.2-108 hours), P< 0.001] were significantly lower in the clofibrate-treated group.Conclusions:
Clofibrate is an effective adjunctive drug in neonatal hyperbilirubinemia, which results in decreased TSB level and reduced duration of phototherapy in late pre-term newborns.Key words
Full text:
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Index:
IMSEAR
Main subject:
Phototherapy
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Bilirubin
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Female
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Humans
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Male
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Infant, Newborn
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Infant, Premature
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Double-Blind Method
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Clofibrate
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Combined Modality Therapy
Type of study:
Clinical_trials
Language:
En
Journal:
Indian J Med Sci
Year:
2009
Type:
Article