Use of rituximab in pemphigus patients with chronic viral hepatitis: Report of three cases.
Indian J Dermatol Venereol Leprol
; 2014 Spt-Oct ; 80 (5): 422-426
Article
in En
| IMSEAR
| ID: sea-154925
ABSTRACT
Use of rituximab in patients with chronic viral hepatitis can worsen pre-existing hepatitis or reactivate occult infection. There are no reports of use of rituximab in pemphigus patients with co-existing viral hepatitis. Herein, we report three pemphigus patients with co-existing chronic viral hepatitis (hepatitis C (n = 2), hepatitis B (n = 1)), who were treated successfully with rituximab under close supervision and concurrent antiviral drug administration. There was no derangement of the liver function tests or increase in viral load in any of the patients. By incorporating good collaboration with a hepatologist and close follow-up, such patients can be managed successfully with biologic therapies when the conventional treatment modalities have failed.
Key words
Full text:
1
Index:
IMSEAR
Main subject:
Antiviral Agents
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Female
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Humans
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Male
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Pemphigus
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Adult
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Hepatitis B, Chronic
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Hepatitis C, Chronic
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Dermatologic Agents
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Antibodies, Monoclonal, Murine-Derived
Language:
En
Journal:
Indian J Dermatol Venereol Leprol
Year:
2014
Type:
Article