Comparative Study of Misoprostol Versus Dinoprostone for Induction of Labour.

ABSTRACT

Induction of labour means initiation of uterine contractions (after the period of viability) by any method (medical, surgical or combined) for the purpose of vaginal delivery. It is helpful when the risks of continuation of pregnancy either to the mother or the fetus is more. Some unfavourable conditions like IUGR, PROM, Post –term pregnancy, IUD, Chorioamnionitis, Maternal medical problems like PIH, Diabetes Mellitus, Renal diseases, COPD, Cardiac diseases may call for induction of labour. Various Pharmacological methods have been introduced for both pre-induction cervical ripening and induction of labour are as follows- 1) Prostaglandins 2) Oxytocin 3) Steroid receptor antagonist-Mifepristone 4) Relaxin This study was conducted on nulliparous females in the age group of 20-30yrs, with gestational age more than 34 wks in the Dept. Of Obstetrics and Gynaecology, Index Medical College Hospital and Research Centre Khudel, Indore over a period of 1 year with a sample size of 100 and they were randomized into Group A-receiving 50mcg of misoprost tablet vaginally and Group B -receiving endocervical cerviprime gel. Hence the purpose of this study is to emphasize that misoprostol is a better alternative than dinoprostone for induction of labour at rural hospital setup by comparing their- 1) Success Rate 2) Induction –delivery interval 3) Number of doses required, their cost effectiveness 4) Maternal complications 5) Fetal complications Among these prostaglandins especially prostaglandin E1,because of their short induction delivery interval, easy availability, low price, easy storage at room temperature, low maternal and fetal complication appear to be especially useful.