Immunoglobulin Levels and CD4 / CD8 Counts in β – Thalassemia Major.
Indian Pediatr
; 2014 Dec; 51(12): 1000-1002
Article
in En
| IMSEAR
| ID: sea-170960
ABSTRACT
Objective:
This cross-sectional study determined the CD4, CD8 counts and serum immunoglobulins in transfusion dependent β - thalassemic patients, and correlated them with anti-HIV, anti-HCV and HBsAg status, number of transfusions, iron overload and splenectomy.Methods:
Patients with acute or chronic diseases (except HIV, Hepatitis B and C), on immunosuppressive drugs or vaccinated within one month prior to study were excluded. CD4, CD8 counts and serum Immunoglobulins were documented.Results:
Increasing transfusions led to higher IgA and IgM as well as a decline in CD4 and CD8 levels. Higher ferritin correlated with high IgM. CD4, CD8 and IgA were significantly higher in splenectomized subjects. HCV correlated significantly with lower IgA values.Conclusion:
Higher transfusion requirement, iron overload, splenectomy and HCV infection correlated with alterations in different immunological parameters.
Full text:
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Index:
IMSEAR
Type of study:
Observational_studies
Language:
En
Journal:
Indian Pediatr
Year:
2014
Type:
Article