Special Histological Types of Breast Carcinoma- A Retrospective Study

ABSTRACT

Background: Breast cancer is a heterogeneous disease that encompasses several distinct entities with remarkably different characteristics . Histological type is the most important aspect of breast carcinoma characteristics. Histological type is associated with differences in epidemiology , diagnostic issues , clinical course & prognosis . Histological special types account for about 25% of breast cancer. Aim-The aim of this study is to identify the incidence and morphology of special types of breast cancers prevalent in our locality along with assessment of IHC status(ER,PR,Her2/neu)for better understanding of rare malignant tumors. Methods: This was aretrospective analysis of all special subtypes of breast cancers over a period of six years (July 2011-June 2017) in the department of Pathology ,VSSIMSAR,Burla,Odisha.Clinicopathological parameters and IHC status were reviewed in all cases. Results: All patients were females with median age of 51 years and undergone modified radical mastectomy. Out of total 448 cases of all breast carcinomas22 cases are of special histologic types.Medullary carcinoma was the most common type ( 7cases )( 13.8%) followed by metaplastic carcinoma(5cases)(22.7%), lobular carcinoma 3(cases )(13.6%),apocrine carcinoma 3(13.6%)cases, papillary carcinoma2(9%)cases, one(4.5%)case each of mucinous carcinoma and sebaceous carcinoma. Conclusion: The identification of the special types has a significant utility in luminal breast cancers and should be considered in therapeutic algorithm.