Screening of liver protective effect of ethanolic leaf extract of Callicarpa lanata (EECL) in ethanol induced hepatotoxicity in wister rats
Article
| IMSEAR
| ID: sea-200071
ABSTRACT
Background:
The ethanolic extract of Callicarpa lanata (EECL), belonging to the family Verbenaceae, were studied for hepatoprotective activity in Wister rats with liver damage induced by ethanol.Methods:
Ethanol treated rats showed significant increase in the levels of serum enzyme activities, total bilirubin and reduction in total proteins reflecting the liver injury caused by ethanol. EECL, at a dose of 400 and 200mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Alkaline Phosphate (SALP), Gama Glutamyl Transpeptidase (GGTP), total Bilirubin to a significant extent and also significantly increased the levels of total protein in a dose dependent manner.Results:
The results were highly significant at dose level of 400mg/kg body weight (p <0.01) and significant at dose level of 200mg/kg body weight (p <0.05). The effects of EECL at both levels were comparable with standard drug silymarin. The hepatoprotective activity was also supported by histopathological studies of liver tissue.Conclusions:
In-vivo hepatoprotective activity of ethanolic leaf extract of Callicarpa lanata (EECL) against Ethanol induced acute liver injury in rats showed significant results in a dose dependent manner.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Diagnostic study
/
Screening study
Year:
2019
Type:
Article
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