Correlation of Serum and Urine Sialic Acid Levels with Lipid Profile and Anthropometric Indices in Type 2 Diabetes Mellitus and Diabetic Nephropathy

ABSTRACT

Introduction:Sialic acid is a component of vascular cell membranes; the elevated levels indicate excessive vascular damage leading to diabetic complications. Therefore sialicacid can be considered to be newly established potential risk factor for the development of diabetic nephropathy. Aims:To study the correlation between sialic acid levels with lipid profile and anthropometric variables in type 2 diabetes mellitus and type 2 diabetics with nephropathy. Study Design:Case control study Place and duration of study study was conducted at department of biochemistry and department of medicine at aj institute of medical sciences, mangalore for a period of 2 years.Methodology:Study population included 75 subjects in the age group of 40-70 years out of whom 25 subjects were type 2 diabetics (newly diagnosed or known diabetics on treatment without any complications), 25 subjects were type 2 diabetics with nephropathyand 25 were age andsex matched normal controls. Serum and urine sialic acid, lipid profile and anthropometric variables were measured in study subjects: