Detection of alpha thalassaemia in sickle cell trait patients by Hb-Bart's screening & quantitation of Hb-A & Hb-S.
Article
in English
| IMSEAR
| ID: sea-20182
ABSTRACT
Haemoglobin fractionation in 27 subjects with sickle cell trait revealed 12 (44%) with sickle cell haemoglobin less than 35 per cent (23.4-34.2%, mean 30.4 +/- 3.3%) suggesting an association of alpha thalassaemia. Electrophoresis of 91 samples of cord blood revealed demonstrable amounts of haemoglobin Bart's in 7 (7.7%); six between 5 and 10 per cent and one with less than 2 per cent. It appeared that the six infants with higher amounts of haemoglobin Bart's were homozygous for alpha-thalassaemia + (-a/-a) genotypes and one was heterozygous for alpha-thalassaemia + (-a/aa) Results of haemoglobin electrophoresis done on 2754 blood samples analysed from hospital records, retrospectively did not reveal haemoglobin-H and haemoglobin Constant Spring in any of the samples.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Sickle Cell Trait
/
Thalassemia
/
Humans
/
Hemoglobin A
/
Hemoglobin, Sickle
/
Hemoglobins, Abnormal
/
Infant, Newborn
/
Fetal Blood
/
Anemia, Sickle Cell
Type of study:
Diagnostic study
/
Screening study
Language:
English
Year:
1989
Type:
Article
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