Serum Cystatin C as a Marker for Early Renal Impairment in Individuals with Type 2 Diabetes Mellitus

ABSTRACT

Background: Diabetic nephropathy (DN) is one of the majormicrovascular complications of diabetes and it is defined as arise in the urinary albumin excretion rate and abnormal renalfunction. Some patient develop advanced renal impairmentwith normal urinary albumin level thus albuminuria is not theperfect marker for the early detection of Diabetic nephropathy.Cystatin C has been suggested one of such markers. The aimof this study was to examine the usefulness of cystatin C as anearly marker of diabetic nephropathy.Methods: It was a retrospective study to evaluate role ofCystatin C in Diabetic nephropathy. 52 patient’s report fromdepartment of medicine in Hindu Rao Hospital, were analysedand compared with age related controls.Results: Association was observed between increased levelsof blood urea, serum creatinine and cystatin C withalbuminuria. The association was statistically significant (pvalue < .05). The significant sensitivity and specificity range forcystatin C was better as compared to blood urea andcreatinine.Conclusion: Cystatin C appears to be a better marker fordetection of diabetic nephropathy in comparison to blood ureaand serum creatinine.