In vitro cytotoxicity and druglikeness of pyrazolines and pyridines bearing benzofuran moiety
Article
| IMSEAR
| ID: sea-210739
ABSTRACT
A series of pyrazolines and pyridines bearing benzofuran moiety (M1–M10) were synthesized for evaluation of theirin vitro cytotoxicity against MCF-7 and HepG2 cell lines. Furthermore, in silico drug-likeness study was carried out.The result of the cytotoxicity of M1–M10 showed that some compounds displayed cytotoxic activity against MCF-7and HepG2 cells. An assessment of in silico drug-likeness study of M1–M10 illustrates that some compounds showedan agreement to the Lipinski, Ghose, Veber, Egan, and Muegge rules with orally bioavailable.
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IMSEAR (South-East Asia)
Year:
2020
Type:
Article
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