Hepatic low density lipoprotein receptor binding and lipid profile in Mastomys natalensis during Plasmodium berghei infection.
Indian J Biochem Biophys
; 1989 Dec; 26(6): 397-9
Article
in En
| IMSEAR
| ID: sea-26553
Plasmodium berghei infection to Mastomys natalensis showed hyper beta-lipoproteinemia. The increase in serum cholesterol is associated with decreased uptake of low density lipoprotein (LDL) by the liver through receptor mediated endocytosis. The membranes prepared from infected M. natalensis exhibit up to 50% decline in high affinity binding sites for human 125I-LDL. Significant increases in serum lipids, cholesterol, triglyceride and lipid peroxide (LPO) contents of liver membrane were observed. Effects of lipid constituents and LPO content of liver membrane in relation to LDL catabolism and other possible mechanisms have been explained.
Full text:
1
Index:
IMSEAR
Main subject:
Plasmodium berghei
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Humans
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Male
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Receptors, LDL
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Lipoproteins
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Liver
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Animals
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Malaria
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Muridae
Language:
En
Journal:
Indian J Biochem Biophys
Year:
1989
Type:
Article