Features of Schistosoma mansoni infection in SCID mice.
Southeast Asian J Trop Med Public Health
; 1997 Dec; 28(4): 838-43
Article
in En
| IMSEAR
| ID: sea-32098
ABSTRACT
Features of Schistosoma mansoni infection in SCID mice, which lack functional T- and B-lymphocytes, were investigated. The retarded development of parasites as well as reduction of liver egg recovery in SCID mice was significantly lower than those in congenic counterpart C.B-17 mice. Furthermore, the rate of parasite recovery from SCID mice with primary infection was always lower than that from C.B-17 mice by 20%, showing the innate resistance to S. mansoni infection. SCID mice vaccinated with UV-attenuated S. mansoni cercariae did not show protective immunity against a homologous challenge infection. The present innate resistance exhibited in SCID mice is discussed in relation to cell mediated immunity of macrophage activation by IFN-gamma which would not involve T-lymphocytes but is initiated by IL-12 and TNF-alpha cytokines. SCID mice may provide novel information on the host-parasite relationship in schistosome infections.
Full text:
1
Index:
IMSEAR
Main subject:
Schistosoma mansoni
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Time Factors
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Schistosomiasis mansoni
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Female
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Male
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Mice, SCID
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Host-Parasite Interactions
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Animals
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Mice
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Mice, Inbred Strains
Language:
En
Journal:
Southeast Asian J Trop Med Public Health
Year:
1997
Type:
Article