Laboratory assessment of thrombolytic therapy in acute myocardial infarction.
Southeast Asian J Trop Med Public Health
; 1993 ; 24 Suppl 1(): 144-8
Article
in En
| IMSEAR
| ID: sea-32108
ABSTRACT
Hemostatic profiles and cardiac enzymes were studied in 55 acute myocardial infarct (AMI) patients to assess SK and rt-PA therapy. Hypofibrinogenemia occurred 85% in SK group and 55% in rt-PA group with high FDP and D-Dimer, indicating systemic fibrinogenolysis and local crosslinked fibrin clot lysis. The incidence of bleeding in SK and rt-PA groups combined with anticoagulants were the same but lower in rt-PA with antiplatelet. The mean FDP was significantly higher in the bleeding group (p < 0.01). Cardiac enzymes CK, CK-MB peak values indicated reperfusion were 26.6%, 60% and 90% in conventional, SK and rt-PA therapy, respectively. Early and late occlusion did not occur either in SK or rt-PA followed by anticoagulants. Late occlusion was found in patients treated with rt-PA and antiplatelet. Mortality rate was 20% in conventional therapy.
Full text:
1
Index:
IMSEAR
Main subject:
Streptokinase
/
Warfarin
/
Blood Coagulation Disorders
/
Blood Coagulation Tests
/
Female
/
Humans
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Male
/
Heparin
/
Drug Monitoring
/
Tissue Plasminogen Activator
Type of study:
Clinical_trials
Language:
En
Journal:
Southeast Asian J Trop Med Public Health
Year:
1993
Type:
Article