Allergic reactions to phenytoin in a general hospital in Singapore.
Asian Pac J Allergy Immunol
; 1996 Dec; 14(2): 65-8
Article
in En
| IMSEAR
| ID: sea-37221
ABSTRACT
Phenytoin is used for the treatment and prevention of fits. We investigated all patients reported to have phenytoin allergy in our hospital and found 42 confirmed cases. Sixty-nine percent were female and 83.3% were Chinese. The mean age of the patients was 46.5 years. The reactions reported were maculopapular rash (71.4%), Stevens-Johnson syndrome (14.3%), fever (4.8%), generalized exfoliative dermatitis (2.4%), toxic epidermal necrolysis (2.4%), vasculitis (2.4%) and agranulocytosis (2.4%). In conclusion, the majority of reported allergic reactions to phenytoin were cutaneous (92.9%) and one fifth of these were potentially life-threatening.
Full text:
1
Index:
IMSEAR
Main subject:
Phenytoin
/
Singapore
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Female
/
Humans
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Male
/
Retrospective Studies
/
Adult
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Drug Hypersensitivity
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Hospitals, General
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Anticonvulsants
Type of study:
Observational_studies
Country/Region as subject:
Asia
Language:
En
Journal:
Asian Pac J Allergy Immunol
Year:
1996
Type:
Article