Diffuse large B cell lymphoma (DLBCL) in Pakistan: an emerging epidemic?
Article
in En
| IMSEAR
| ID: sea-37446
ABSTRACT
There has been a recent concern among oncological clinicians and pathologists of our region regarding the disproportionate increase in the number of patients presenting with diffuse large B cell lymphoma (DLBCL). This prompted us to conduct a thorough, hospital-based epidemiological study in a major referral center of Pakistan. A total of 780 specimens were collected over last half decade from cases classified as adult Non Hodgkin's lymphoma (NHL). Out of these 780, 596 (76.4 %) were diagnosed as DLBCLs. The gender ratio was 2.31 (MF) and the median age was 47.2 years, with an age range of 15-85 years. Nodal-NHLs constituted 42.2 % of all adult NHLs, with the cervical lymph nodes as the most frequent nodal site of presentation. The most frequent extranodal site was the gastro-intestinal tract (GIT), followed by the head and neck. In conclusion, we document an astonishingly high number of DLBCL amounting to an emerging epidemic in Pakistan, with a consideration of probable etiopathogenetic factors.
Full text:
1
Index:
IMSEAR
Main subject:
Pakistan
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Aged, 80 and over
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Aged
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Female
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Humans
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Male
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Prevalence
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Disease Outbreaks
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Lymphoma, B-Cell
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Lymphoma, Large B-Cell, Diffuse
Type of study:
Prevalence_studies
Limits:
Aged80
Country/Region as subject:
Asia
Language:
En
Year:
2005
Type:
Article