Anticarcinogenic effects of an aqueous infusion of cloves on skin carcinogenesis.
Article
in En
| IMSEAR
| ID: sea-38067
ABSTRACT
Spices and flavouring agents are now receiving increasing attention as many of them have been shown to have anticarcinogenic properties. Cloves, sun-dried unopened flower buds from the plant Syzygium aromaticum L, are commonly used as a spice and food flavour. The present study was designed to investigate the chemopreventive action of aqueous infusion of cloves on 9,10-dimethyl benz(a)anthracene (DMBA) and croton oil induced skin carcinogenesis in Swiss mice. The results indicate protection against skin papilloma formation in a dose dependent manner. It has been shown that oral administration of aqueous infusions of clove at a dose of 100 microl/mouse/day not only delays the formation of papilloma but also reduces the incidence of papilloma as well as the cumulative number of papillomas per papilloma bearing mouse. Our observations suggest a promising role for cloves in restriction of the carcinogenesis process.
Full text:
1
Index:
IMSEAR
Main subject:
Papilloma
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Skin Neoplasms
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Plant Extracts
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Carcinogens
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Cell Transformation, Neoplastic
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Administration, Oral
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Chemoprevention
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9,10-Dimethyl-1,2-benzanthracene
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Eugenia
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Animals
Language:
En
Year:
2005
Type:
Article