131I-MIBG scintigraphy in neural crest tumours.
Indian J Cancer
;
1994 Jun; 31(2): 103-10
Article
in English
| IMSEAR
| ID: sea-49812
ABSTRACT
Radioiodinated meta-iodobenzylguanidine (131I-MIBG) has been widely used for the diagnosis of neuroblastomas, pheochromocytomas, paragangliomas and medullary carcinomas of thyroid. We have developed a procedure for preparation of 131I-MIBG and studied its utility in diagnosis of primary and metastatic neural crest tumours. Studies were carried out in 54 patients. Of them 39 cases were of neuroblastomas, 1 pheochromocytoma; 6 operated medullary carcinomas; 5 paragangliomas; 2 Ewing's sarcoma and 1 Rhabdomyosarcoma; The sensitivity for the detection of primary tumours of neuroblastomas was 94% and for the detection of metastasis was 83%; while in the case of paragangliomas and medullary carcinoma, the sensitivity was 75% and 70% respectively. Our experience in the present study shows that 131I-MIBG scintigraphy is a sensitive and specific diagnostic tool to localise primary and metastatic disease of neural crest tumours.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Child
/
Sensitivity and Specificity
/
3-Iodobenzylguanidine
/
Iodine Radioisotopes
/
Iodobenzenes
Type of study:
Diagnostic study
Language:
English
Journal:
Indian J Cancer
Year:
1994
Type:
Article
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