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CD-3 positive extranodal T-cell lymphoma of nasal type with skin involvement.
Indian J Dermatol Venereol Leprol ; 2006 May-Jun; 72(3): 215-7
Article in En | IMSEAR | ID: sea-52747
ABSTRACT
A 40-year-old previously healthy lady presented with nasal obstruction and localized plaques over the right arm. She developed complete nasal obstruction due to a mass in the right nasal cavity and skin lesions that ulcerated to present as ecthyma gangrenosum like lesions. Patient's condition deteriorated fast and she developed icterus with fatal outcome within 4 weeks of developing skin lesions. Nasal and skin biopsy revealed angiocentric T-cell lymphoma, which on immuno-phenotyping revealed CD-3 positive; and CD-20, CD-30, ALK and EMA negativity. She was seronegative for HIV. Final diagnosis of CD-3 positive extranodal T-cell lymphoma of nasal type was made. Extranodal T-cell lymphomas are very aggressive NHLs with poor prognosis. Prognosis depends on histology, stage of the disease and sites of involvement. NK/T cell lymphoma of nasal type is common with EBV association. Skin involvement is rare and is also an indicator of poor prognosis.
Subject(s)
Full text: 1 Index: IMSEAR Main subject: Skin Neoplasms / Female / Humans / Nose Neoplasms / Lymphoma, T-Cell / CD3 Complex / Fatal Outcome / Adult / Ecthyma Type of study: Prognostic_studies Language: En Journal: Indian J Dermatol Venereol Leprol Year: 2006 Type: Article
Full text: 1 Index: IMSEAR Main subject: Skin Neoplasms / Female / Humans / Nose Neoplasms / Lymphoma, T-Cell / CD3 Complex / Fatal Outcome / Adult / Ecthyma Type of study: Prognostic_studies Language: En Journal: Indian J Dermatol Venereol Leprol Year: 2006 Type: Article