Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats.
Indian J Exp Biol
;
2005 Apr; 43(4): 351-5
Article
in English
| IMSEAR
| ID: sea-55793
ABSTRACT
Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Wistar
/
Analgesics, Non-Narcotic
/
Beta Carotene
/
Disease Models, Animal
/
Chemical and Drug Induced Liver Injury
/
Liver
/
Animals
/
Acetaminophen
/
Antioxidants
Language:
English
Journal:
Indian J Exp Biol
Year:
2005
Type:
Article
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