Gabapentin attenuates acute hypoxic stress-induced behavioral alterations and oxidative damage in mice: possible involvement of GABAergic mechanism.
Indian J Exp Biol
;
2008 Mar; 46(3): 159-63
Article
in English
| IMSEAR
| ID: sea-57141
ABSTRACT
The effect of gabapentin has been investigated on acute hypoxic stress-induced behavioral alterations and oxidative damage in mice. Mice were subjected to hypoxia for 2 hr. Treatment with gabapentin (50 and 100 mg/kg) significantly increased ambulatory movements, exerted anti-anxiety like effect and reduced oxidative damage in mice subjected to acute hypoxic stress. Treatment with picrotoxin (1.0 mg/kg) per se had no significant effect on behavioral and biochemical parameters of stressed mice. Treatment with muscimol (0.05 mg/kg) per se significantly increased the locomotor activity of stressed mice, exerted significant anti anxiety effect and significantly reduced the oxidative damage. Further, pretreatment with picrotoxin (1.0 mg/kg) significantly blocked whereas pretreatment with muscimol (0.05 mg/kg) significantly potentiated the neuroprotective effect of gabapentin. These results suggest that gabapentin produces its neuroprotective effect in mice subjected to acute hypoxic stress through GABA(A) receptor mechanism.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Picrotoxin
/
Spectrophotometry
/
Brain
/
Lipid Peroxidation
/
Analysis of Variance
/
Oxidative Stress
/
Cyclohexanecarboxylic Acids
/
Gamma-Aminobutyric Acid
/
Amines
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2008
Type:
Article
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