Biodegradable dental implants of ciprofloxacin beta-cyclodextrin inclusion complex in the treatment of periodontitis.
Indian J Exp Biol
;
1999 Mar; 37(3): 305-7
Article
in English
| IMSEAR
| ID: sea-58251
ABSTRACT
Dental implants of ciprofloxacin beta-cyclodextrin inclusion complex were formulated using poly (epsilon-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out in ten patients with acute peridontitis. Various clinical parameters, viz. gingival index, plaque score, attachment gain, reduction in pocket depth were evaluated at 10, 20, 30, 40 days of treatment and compared with placebo as control. A significant (P < 0.0001) improvement in the healing of periodontal pockets treated with ciprofloxacin beta-cyclodextrin implant was observed in most of the clinical parameters. Estimation of gingival crevicular fluids (GCF) for the drug content revealed that drug levels above the minimum inhibitory concentration (10.2 micrograms/mg) for many of the periodontal pathogens were maintained throughout the period of study (40 days). This confirms the clinical efficacy of the dose and the duration of the study. It was found that biodegradable carrier was better accepted than the non-biodegradable carriers reported earlier.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Periodontitis
/
Humans
/
Ciprofloxacin
/
Dental Implants
/
Adult
/
Cyclodextrins
/
Dental Materials
/
Beta-Cyclodextrins
/
Drug Implants
/
Anti-Infective Agents
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian J Exp Biol
Year:
1999
Type:
Article
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