In vivo inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate.
Indian J Exp Biol
;
2002 Mar; 40(3): 258-61
Article
in English
| IMSEAR
| ID: sea-58634
ABSTRACT
Intraperitoneal injection of rats with diethyldithiocarbamate (1.2 g/kg body wt) led to maximum diminution of superoxide dismutase activity at 1 hr by 86 and 84% in liver and red blood cell respectively with a gradual return to the normal level at 48 hr after administration of injection. Significant inhibition of selenium-dependent glutathione peroxidase was also observed, which returned to normal at 48 hr after administration of injection. However, maximum decline in its activity was at 12 hr by 52 and 73% in liver and red blood cells respectively. No significant difference in tissue level of selenium-independent glutathione peroxidase was observed during time course study after diethyldithiocarbamate administration. It is possible that inhibition of superoxide dismutase by diethyldithiocarbamate leads to accumulation of superoxide anion which in turn inactivates selenium-dependent glutathione peroxidase by its reaction with selenium at the active site of the enzyme.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Selenium
/
Superoxide Dismutase
/
Male
/
Chelating Agents
/
Rats, Wistar
/
Ditiocarb
/
Enzyme Inhibitors
/
Erythrocytes
/
Glutathione Peroxidase
Language:
English
Journal:
Indian J Exp Biol
Year:
2002
Type:
Article
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