Involvement of potassium channels in hypoglycemic effect of sertraline.
Indian J Exp Biol
; 2006 Feb; 44(2): 120-2
Article
in En
| IMSEAR
| ID: sea-58901
ABSTRACT
Effect of 21 days administration of sertraline (30 mg/kg, po) in streptozotocin (55 mg/kg, ip) induced diabetic and non-diabetic rats produced hypoglycemia in diabetic and non-diabetic rats. Pinacidil (1mg/kg, po), when co-administered with sertraline or glimepiride antagonized the decrease in glucose levels in diabetic rats. Pinacidil (10(-6)-10(-3) M) produced dose dependent relaxation (EC50-1.58 x 10(-5) M). Neither sertraline nor glimepiride had any effect on the resting tension of ileum preparation. Both sertraline and glimepiride antagonized competitively the pinacidil-induced relaxation. The pA2 values of sertraline and glimepiride reversal of pinacidil-induced relaxation were 5.5 and 6.2 respectively. These studies suggest the involvement of K+ channels in hypoglyceimic effects of sertraline.
Full text:
1
Index:
IMSEAR
Main subject:
Rats
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Sulfonylurea Compounds
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Vasodilation
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Vasodilator Agents
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Potassium Channels
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Rats, Wistar
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Streptozocin
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Pinacidil
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Sertraline
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Diabetes Mellitus, Experimental
Language:
En
Journal:
Indian J Exp Biol
Year:
2006
Type:
Article