Effects of organophosphorus insecticide phosphomidon on antioxidant defence components of human erythrocyte and plasma.
Indian J Exp Biol
; 1992 Jan; 30(1): 65-7
Article
in En
| IMSEAR
| ID: sea-59056
ABSTRACT
Effect of organophosphorus insecticide, phosphomidon (250 and 500 ppm) on human erythrocyte and plasma were studied in vitro to get insight into the cellular antioxidant defence mechanism and malondialdehyde formation. The antioxidant defence system of erythrocyte was altered as evident by depression of glutathione reductase, glucose 6 phosphate dehydrogenase, whereas the level of reduced glutathione, glutathione peroxidase, glutathione-S-transferase, superoxidedismutase and catalase were stimulated. In the case of plasma fraction, glutathione reductase, glutathione peroxidase, glutathione-s-transferase, glucose-6-phosphate dehydrogenase, superoxide dismutase and levels of reduced glutathione were significantly depressed and the malondialdehyde formation and catalase activity were elevated indicating the less adaptive response of plasma to protect it from oxidative damage.
Full text:
1
Index:
IMSEAR
Main subject:
Oxidation-Reduction
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Phosphamidon
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Plasma
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Humans
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Male
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Adult
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Dose-Response Relationship, Drug
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Erythrocytes
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Insecticides
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Malondialdehyde
Language:
En
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article