Inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate: effect of pre-administration of alpha-tocopherol.
Indian J Exp Biol
;
2007 May; 45(5): 465-8
Article
in English
| IMSEAR
| ID: sea-60172
ABSTRACT
Rats pre-administered with alpha-tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of alpha-tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and alpha-tocopherol act in a complementary fashion to block free radical formation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Superoxide Dismutase
/
Time Factors
/
Male
/
Rats, Wistar
/
Ditiocarb
/
Cytoprotection
/
Alpha-Tocopherol
/
Free Radicals
/
Glutathione Peroxidase
Type of study:
Evaluation studies
Language:
English
Journal:
Indian J Exp Biol
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS