Effect of Aerva lanata on calcium oxalate urolithiasis in rats.
Indian J Exp Biol
; 2006 Dec; 44(12): 981-6
Article
in En
| IMSEAR
| ID: sea-60415
ABSTRACT
Calcium oxalate (CaOx) stone was induced in rats using 0.75% of ethylene glycol in drinking water for 28 days. Ethylene glycol treated rats showed significant increase in the activities of oxalate synthesizing enzymes such as glycolic acid oxidase (GAO) in liver and lactate dehydrogenase (LDH) in liver and kidney. CaOx crystal deposition, as indicated by increased excretion of stone-forming constituents in urine, such as calcium, oxalate, uric acid, phosphorus and protein and decreased concentration of inhibitors, such as citrate and magnesium was observed in ethylene glycol induced urolithic rats. Histopathological studies also confirmed the deposition of CaOx crystals. Administration of Aerva lanata aqueous suspension (2g/kg body wt/dose/day for 28 days) to CaOx urolithic rats had reduced the oxalate synthesizing enzymes, diminished the markers of crystal deposition in the kidney. The results of the present study confirmed that A. lanata can be used as an curative agent for urolithiasis.
Full text:
1
Index:
IMSEAR
Main subject:
Rats
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Male
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Calcium Oxalate
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Plant Extracts
/
Analysis of Variance
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Rats, Wistar
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Amaranthaceae
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Alcohol Oxidoreductases
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Urolithiasis
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L-Lactate Dehydrogenase
Language:
En
Journal:
Indian J Exp Biol
Year:
2006
Type:
Article