Influence of antiangiogenic fraction from Diogenes avarus (Heller) on fertility and implantation in mice.

Pathare, Sujala; Bhivgade, D A; Indap, Madhavi

Pathare, Sujala; Bhivgade, D A; Indap, Madhavi.

Indian J Exp Biol ; 2004 Jun; 42(6): 581-8

Article in English | IMSEAR | ID: sea-60918

ABSTRACT

ABSTRACT

The methanol extract isolated from hermit crab, D. avarus degenerated ovarion and uterine tissues in cyclic and pregnant mice, treated before and after the implantation. Immunohistochemical staining using CD31 and Factor VIII specific to endothelial cells showed reduction in microvessel density. The hormonal assay showed decrease in the progesterone secretion in all experimental mice.

Subject(s)

Angiogenesis Inhibitors/pharmacology; Animals; Anomura; Platelet Endothelial Cell Adhesion Molecule-1/biosynthesis; Embryo Implantation; Endothelial Cells/metabolism; Endothelium, Vascular/metabolism; Factor VIII/biosynthesis; Female; Fertility; Immunohistochemistry; Male; Methanol/metabolism; Mice; Microcirculation; Microscopy, Electron; Ovary/metabolism; Pregnancy; Pregnancy, Animal; Progesterone/blood; Time Factors; Uterus/metabolism

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Ovary / Embryo Implantation / Progesterone / Time Factors / Uterus / Female / Male / Factor VIII / Pregnancy / Pregnancy, Animal Language: English Journal: Indian J Exp Biol Year: 2004 Type: Article

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