Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth.
Indian J Exp Biol
; 2003 Aug; 41(8): 890-4
Article
in En
| IMSEAR
| ID: sea-61211
ABSTRACT
Column chromatographic fractionation of essential oil obtained by hydrodistillation from the flowering tops of S. ixiocephala resulted in the isolation of beta-caryophyllene, fenchyl acetate, T-cadinol and a new sesquiterpene alcohol for which a name ixiocephol has been proposed. The beta-caryophyllene and fenchyl acetate were identified by Co-TLC with authentic samples whereas T-cadinol and ixiocephol were structurally elucidated by UV, IR, 1H NMR, 13C NMR and Mass spectral data. The GC-MS analysis of the essential oil has also revealed the presence of various monoterpenoids and sesquiterpenoids. The essential oil of S. ixiocephala demonstrated a dose dependant anti-inflammatory activity in carrageenan-induced rat paw oedema. It has also revealed good activity in cotton pellet granuloma and adjuvant induced arthritis model in rats.
Full text:
1
Index:
IMSEAR
Main subject:
Arthritis, Experimental
/
Rats
/
Female
/
Male
/
Oils, Volatile
/
Granuloma, Foreign-Body
/
Anti-Inflammatory Agents, Non-Steroidal
/
Rats, Wistar
/
Acanthaceae
/
Disease Models, Animal
Language:
En
Journal:
Indian J Exp Biol
Year:
2003
Type:
Article