Effect of angiotensin II on liposome uptake by the rat brain in vivo.
Indian J Exp Biol
;
1999 Sep; 37(9): 871-5
Article
in English
| IMSEAR
| ID: sea-62110
ABSTRACT
Studies have been performed to assess the possibility of using small unilamellar liposomes as therapeutic carriers to the brain of hypertensive rats. Rats were made temporal hypertensive by the infusion of angiotensin II (AII; 15 micrograms in 1 ml) through their right common carotid artery. Another control group was infused with physiological saline. Free 125iodine-BSA (125I-BSA) and 125I-BSA encapsulated liposomes (average diameter approximately equal to 100 nm) were injected in the tail vein 2 min after the infusion of AII or saline. Plasma radioactivity was monitored at different times up to 15 min when the cerebral uptake of 125I-BSA was determined. While a little variation in plasma clearance pattern of liposomes in hypertensive and control group was noticed, the uptake by cerebral tissues was markedly higher in hypertensive group. Analysis of pharmacokinetic parameters in relation to cerebral uptake indicated AII induced a short term opening of the blood-brain barrier (BBB) resulting in an increased cerebral uptake. Positively charged liposomes was found to be most effective in hypertensive state.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Brain
/
Angiotensin II
/
Drug Carriers
/
Blood-Brain Barrier
/
Area Under Curve
/
Disease Models, Animal
/
Hypertension
/
Liposomes
/
Animals
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Exp Biol
Year:
1999
Type:
Article
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