Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India.
Article
in En
| IMSEAR
| ID: sea-64155
ABSTRACT
BACKGROUND:
Factor V Leiden has been reported in 2%-30% of patients with portal vein thrombosis. This wide variation makes it difficult to assess the importance of factor V Leiden as a predisposing factor.METHODS:
Factor V Leiden was determined by restriction fragment length polymorphism in 112 patients with portal vein thrombosis, 104 with deep vein thrombosis and 98 control subjects.RESULTS:
Only 3/112 (3%) patients with portal vein thrombosis had factor V Leiden, compared to 1/98 (1%) controls and 16/104 (15%) with deep vein thrombosis; of these, 3, 1 and 15, respectively, were heterozygous for this mutation.CONCLUSION:
Factor V Leiden contributes little, if at all, to the development of portal vein thrombosis in southern India.
Full text:
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Index:
IMSEAR
Main subject:
Portal Vein
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Splenic Vein
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Polymorphism, Restriction Fragment Length
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Aged
/
Female
/
Humans
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Male
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Factor V
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Child
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Child, Preschool
Country/Region as subject:
Asia
Language:
En
Year:
2006
Type:
Article