Primary pulmonary hypertension in cirrhosis of liver.
Article
in En
| IMSEAR
| ID: sea-64570
ABSTRACT
BACKGROUND:
Primary pulmonary hypertension (PPH) is a grave association of portal hypertension, and is potentially fatal in liver transplant candidates.AIM:
To investigate the prevalence of PPH among cirrhotics with portal hypertension.METHODS:
43 cirrhotics with portal hypertension (Child B 22, C 14), after screening for cardiopulmonary diseases, were evaluated by hemodynamic study.RESULTS:
PPH was detected in 2 cases (4.7%), both in Child B, hepatitis B and C viruses being the etiologies. Neither had portal axis thrombosis. Two other cases also had pulmonary hypertension, but with high pulmonary capillary wedge pressure (PCWP). The 41 cases without and 2 cases with PPH had, respectively, mean pulmonary artery pressure (MPAP) 16.3 (5.9) mmHg, 26 mmHg and 33 mmHg; PCWP 11.5 (6.7) mmHg, 12 mmHg and 11 mmHg; transpulmonary pressure gradient 4.8 (2.6) mmHg (n = 27), 14 mmHg and 22 mmHg; and pulmonary vascular resistance 80.2 (55.8) dyne.sec.cm-5 (n = 27), 155.6 dyne.sec.cm-5 and 366.7 dyne.sec.cm-5. No correlation of MPAP was found with either Child-Pugh scoring (r2 = 0.0347) or with hepatic venous pressure gradient (r2 = 0.0021).CONCLUSION:
PPH has a prevalence of 4.7% among cirrhotics with portal hypertension; it bears no relation with severity of liver disease.
Full text:
1
Index:
IMSEAR
Main subject:
Female
/
Humans
/
Male
/
Pulmonary Wedge Pressure
/
Prevalence
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Prospective Studies
/
Adult
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Hypertension, Portal
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Hypertension, Pulmonary
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Liver Cirrhosis
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Language:
En
Year:
1999
Type:
Article