Effects of flunarizine on dopamine dependent behaviours in rats.
Indian J Med Sci
; 1999 Feb; 53(2): 43-8
Article
in En
| IMSEAR
| ID: sea-68938
ABSTRACT
1. Radio-ligand binding study has demonstrated that flunarizine has a high affinity for the rat striatal D 2 dopamine (DA) receptors. 2. In the present behavioural study conducted in rats it was observed that flunarizine, unlike the postsynaptic striatal D 2 DA receptor agonist apomorphine, did not induce stereotyped behaviour (SB) in rats. This indicates that flunarizine does not act as an agonist at the postsynaptic striatal D 2 DA receptors. 3. Flunarizine however, like the postsynaptic striatal D 2 DA receptor antagonist haloperiodal, inhibited the conditioned avoidance response, induced catalepsy and antagonized the SB induced by the DA agonists apomorphine and methamphetamine. 4. Our findings indicate that flunarizine acts as a postsynaptic striatal D 2 DA receptor antagonist.
Full text:
1
Index:
IMSEAR
Main subject:
Rats
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Stereotyped Behavior
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Avoidance Learning
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Behavior, Animal
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Male
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Calcium Channel Blockers
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Flunarizine
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Apomorphine
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Dopamine
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Catalepsy
Language:
En
Journal:
Indian J Med Sci
Year:
1999
Type:
Article