Strategy for preventing vertical transmisssion of HIV : Bombay experience.
Indian Pediatr
; 2001 Feb; 38(2): 132-8
Article
in En
| IMSEAR
| ID: sea-6952
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of an interventional regime to reduce the perinatal mode of transmission of human immunodeficiency virus (HIV).DESIGN:
Prospective.SETTING:
Perinatal HIV clinic at a university affiliated maternity hospital. SUBJECT &METHODS:
After adequate counseling, consenting HIV positive women were offered perinatal intervention (i) administration of 400 mg of zidovudine (AZT) per day for the last 6 weeks of the antenatal period; (ii) delivery by elective Caesarian section before rupture of membrances; (iii) oral AZT powder in the dose of 8 mg per kilogram daily to the infant for the first 6 weeks of life; and (iv) avoidance of breast milk. The infants were scheduled for regular follow-up for at least 18 months. A definitive diagnosis of infectivity in the infant was ascertained by two positive enzyme-linked immunosorbent assays (ELISA) at the age of 9 months and between 15 to 18 months.RESULTS:
Of the 107 mother-infant pairs enrolled, 22 infants were lost to follow-up, 15 were under 18 months of age at the time of this analysis and 2 infants died without a diagnosis. Of the remaining 68 infants followed up, 4 tested HIV positive at 18 months. Of the 229 women-infant pairs who did not receive perinatal intervention, 55 infants followed up to 15-18 months were found to be infected.CONCLUSION:
This interventional strategy significantly reduced the mother to child transmission of HIV. However, the results need to be substantiated by larger studies.
Full text:
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Index:
IMSEAR
Main subject:
Pregnancy Complications, Infectious
/
Female
/
Humans
/
Pregnancy
/
Zidovudine
/
HIV Infections
/
Prospective Studies
/
Infectious Disease Transmission, Vertical
/
Anti-HIV Agents
/
Adult
Type of study:
Observational_studies
Country/Region as subject:
Asia
Language:
En
Journal:
Indian Pediatr
Year:
2001
Type:
Article