A clinicopathologic study of mantle cell lymphoma in a single center study in India.
Indian J Pathol Microbiol
;
2008 Jul-Sep; 51(3): 315-22
Article
in English
| IMSEAR
| ID: sea-72871
ABSTRACT
We present clinical features, histopathology and results of treatment in cases of mantle cell lymphoma (MCL) at our hospital. We had 93 cases (2.1%) of MCL out of total 4301 cases of non-Hodgkin's lymphoma (NHL) in a 4-year period. It included 68 cases (1.7%) of MCL from 3987 cases of NHL diagnosed on histopathology. Remaining 25 cases (7.9%) diagnosed solely on peripheral blood examination were excluded. Thirty-six (85%) patients had advanced-stage disease. Sixty-three were nodal and five were extranodal (all gastrointestinal tract). Common patterns were diffuse (64%), nodular (25%) and mantle zone type (11%). Sixty-two cases had lymphocytic while six had blastic morphology (all nodal). Tumor cells expressed CD20 (100%), CD43 (94%), CD5 (89%) and cyclin D1 (85%). Bone marrow was involved in 25 (59%) cases. Thirty-two patients could be treated. Median recurrence-free survival was 22.23 months. Diffuse pattern of nodal involvement had a lower overall survival.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Bone Marrow
/
Aged
/
Female
/
Humans
/
Male
/
Survival Analysis
/
CD5 Antigens
/
Antigens, CD20
/
Adult
/
Cyclin D1
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2008
Type:
Article
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