Inducible clindamycin resistance among clinical isolates of Staphylococci.
Indian J Pathol Microbiol
;
2009 Jan-Mar; 52(1): 49-51
Article
in English
| IMSEAR
| ID: sea-74741
ABSTRACT
INTRODUCTION:
Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide, lincosamide and streptogramin antibiotics. This study was undertaken to detect the presence of inducible clindamycin resistance among clinical isolates of staphylococci. MATERIALS ANDMETHODS:
The detection of inducible clindamycin resistance was performed by D-test using erythromycin and clindamycin discs as per CDC guidelines.RESULTS:
Among the 244 clinical isolates of staphylococci studied, 32 (13.1%) showed inducible clindamycin resistance and belonged to the MLSBi phenotype. Among the MLS B i phenotypes, 10 isolates were methicillin-resistant Staphylococcus aureus (38.4% of the total MRSA), 16 were methicillin-sensitive Staphylococcus aureus (12.9% of the total MSSA) and 6 were coagulase-negative staphylococci (6.3% of the total CONS).CONCLUSION:
The test for inducible resistance to clindamycin should be included in the routine antibiotic susceptibility testing, as it will help in guiding therapy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Staphylococcal Infections
/
Staphylococcus
/
Staphylococcus aureus
/
Humans
/
Clindamycin
/
Microbial Sensitivity Tests
/
Erythromycin
/
Drug Resistance, Bacterial
/
Anti-Bacterial Agents
Type of study:
Practice guideline
Language:
English
Journal:
Indian J Pathol Microbiol
Year:
2009
Type:
Article
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