Paracetamol poisoning in children.
Indian J Pediatr
;
1998 May-Jun; 65(3): 393-400
Article
in English
| IMSEAR
| ID: sea-83797
ABSTRACT
Paracetamol (acetaminophen) has become an antipyretic drug of choice. Due to its widespread use, toxicity secondary to overdose has increased in recent years. Children are especially vulnerable to accidental exposure due to non availability of child proof containers in India. The main clinical features of acute toxicity include anorexia, vomiting, abdominal pain, jaundice, hematuria and metabolic acidoses. Diagnosis is based on history and laboratory findings of acidosis and abnormal liver function tests. N-acetylcysteine is the specific antidote. This article reviews in detail the toxicokinetics, pathophysiology, clinical features and management of paracetamol poisoning in children.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Pregnancy
/
Child
/
Child, Preschool
/
Adolescent
/
Analgesics, Non-Narcotic
/
Diagnosis, Differential
/
Dose-Response Relationship, Drug
Type of study:
Diagnostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Pediatr
Year:
1998
Type:
Article
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