Clinical profile of giardiasis and comparison of its therapeutic response to metronidazole and tinidazole.
Article
in En
| IMSEAR
| ID: sea-85994
ABSTRACT
Seventy five cases (50 males, 25 females; mean age 20.2 +/- 5.8 years), whose stools were positive for cysts and/or trophozoites of Giardia lamblia, were studied for their clinical profile and therapeutic response to metronidazole and tinidazole. Maximum frequency of cases (41.2%) was noted upto 20 years of age, and it declined with advancing age. A majority of them (41.3%) presented with non-specific symptoms while 38.6% were asymptomatic parasite carriers. Features of malabsorption were observed in 12% of cases and 8% presented with acute illness, having explosive, watery, foul smelling diarrhoea along with crampy upper abdominal discomfort. Most of them (62.5%) had blood group A. Tinidazole (97.5%) was more efficacious (P less than 0.01) than metronidazole (54%) in a single dose of 50 mg/Kg, with good tolerance. Tinidazole can be recommended for the treatment of giardiasis in individual cases as well as in families and close communities.
Full text:
1
Index:
IMSEAR
Main subject:
Tinidazole
/
Female
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Humans
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Male
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Follow-Up Studies
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Adolescent
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Age Factors
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Giardiasis
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Adult
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Metronidazole
Type of study:
Observational_studies
/
Prognostic_studies
Language:
En
Year:
1991
Type:
Article