Short term anti-tubercular drug therapy and hepatic microsomal enzyme activity. Antipyrine metabolism as an index.
Article
in En
| IMSEAR
| ID: sea-91112
ABSTRACT
The effect of short course chemotherapy on the drug metabolising capacity of the liver was studied in 7 newly diagnosed pulmonary tuberculosis patients, using antipyrine as a model drug. Antipyrine elimination half-life and plasma clearance rate were not significantly altered by 3 weeks of therapy. It is concluded that short course chemotherapy does not affect antipyrine metabolising enzyme activity.
Full text:
1
Index:
IMSEAR
Main subject:
Saliva
/
Time Factors
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Tuberculosis, Pulmonary
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Humans
/
Male
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Microsomes, Liver
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Antipyrine
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Adult
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Drug Evaluation
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Antitubercular Agents
Type of study:
Prognostic_studies
Language:
En
Year:
1990
Type:
Article