Acute superior mesenteric vein thrombosis associated with factor V 'Leiden' gene mutation.
Article
in En
| IMSEAR
| ID: sea-91364
ABSTRACT
OBJECTIVES:
To study thrombophilia states in Indian patients with acute spontaneous superior mesenteric vein thrombosis (SMVT).METHODS:
Two men with this condition, a 56 year old and a 31 year old presenting with acute SMVT, demonstrated on CT scan, were subjected to a thrombophilia screen consisting of Protein C, S, antithrombin levels, lupus anticoagulant, anticardiolipin antibodies, fibrinogen levels, factor VIII levels, factor V 'Leiden' gene mutation, and paroxysmal nocturnal hematuria screen.RESULTS:
A thrombophilia screen showed factor V 'Leiden' gene mutation (heterozygous) in both cases. Additionally, the first patient had high fibrinogen levels and the second high factor VIII levels. Both patients are currently on long-term anticoagulation.CONCLUSION:
Factor V 'Leiden' gene mutation in association with other thrombophilic factors may predispose to spontaneous superior mesenteric vein thrombosis.
Full text:
1
Index:
IMSEAR
Main subject:
Humans
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Male
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Factor V
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Acute Disease
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Adult
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Thrombophilia
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Venous Thrombosis
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Heterozygote
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Mesenteric Vascular Occlusion
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Mesenteric Veins
Language:
En
Year:
2003
Type:
Article