Sickle haemoglobin, G-6PD deficiency and malaria in western Orissa.
Article
in En
| IMSEAR
| ID: sea-92805
ABSTRACT
Sixty cases of malaria were screened for sickle haemoglobin and G-6PD deficiency. Plasmodium vivax was detected in 40 (66%) and Plasmodium falciparum in 21 (35%) cases, with six of the latter having cerebral manifestation. Sickle Hb was found in 7 (11.5%) patients and G-6PD deficiency in 3 (5%) cases. Both patients with SS disease had vivax malaria, while of 5 with sickle cell trait 3 had only vivax, one only falciparum and one mixed infection. Amongst G-6PD deficient patients one had vivax and two falciparum malaria. One of the latter had both SC trait and G-6PD deficiency. Thus, adult persons with SS disease or SC trait were not found to be resistant to either vivax or falciparum malaria. A high frequency (5%) of G-6PD deficiency amongst malaria patients warrants a caution against indiscriminate use of 8-aminoquinoline drugs.
Full text:
1
Index:
IMSEAR
Main subject:
Plasmodium falciparum
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Plasmodium vivax
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Sickle Cell Trait
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Humans
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Glycogen Storage Disease Type I
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Child
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Adolescent
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Adult
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India
/
Infant
Country/Region as subject:
Asia
Language:
En
Year:
1990
Type:
Article