Vitamin K Supplement Along with Vitamin D and Calcium Reduced Serum Concentration of Undercarboxylated Osteocalcin While Increasing Bone Mineral Density in Korean Postmenopausal Women over Sixty-Years-Old
Journal of Korean Medical Science
; : 1093-1098, 2011.
Article
in En
| WPRIM
| ID: wpr-100570
Responsible library:
WPRO
ABSTRACT
There are inconsistent findings on the effects of vitamin K on bone mineral density (BMD) and undercarboxylated osteocalcin (UcOC). The present intervention study evaluated the effect in subjects over 60-yr-old. The vitamin K group (vitamin K + vitamin D + calcium supplement; 15 mg of vitamin K2 [menatetrenone] three times daily, 400 IU of vitamin D once a day, and 315 mg of calcium twice daily) and the control group (vitamin D + calcium supplement) were randomly assigned. During the six months of treatment, seventy eight women participated (38 in the vitamin K group and 40 in the control group) and 45 women completed the study. The baseline characteristics of study participants did not differ between the vitamin K and the control groups. In a per protocol analysis after 6 months, L3 bone mineral density has increased statistically significantly in the vitamin K group compared to the control group (0.01 +/- 0.03 g/cm2 vs -0.008 +/- 0.04 g/cm2, P = 0.049). UcOC concentration was also significantly decreased in the vitamin K group (-1.6 +/- 1.6 ng/dL vs -0.4 +/- 1.1 ng/dL, P = 0.008). In conclusion, addition of vitamin K to vitamin D and calcium supplements in the postmenopausal Korean women increase the L3 BMD and reduce the UcOC concentration.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Vitamin D
/
Vitamin K
/
Bone Density
/
Osteocalcin
/
Calcium
/
Postmenopause
/
Dietary Supplements
/
Republic of Korea
Type of study:
Guideline
Limits:
Aged
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2011
Type:
Article