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Environmental pollutants and Alzheimer's disease / 生理学报
Acta Physiologica Sinica ; (6): 740-766, 2023.
Article in Zh | WPRIM | ID: wpr-1007788
Responsible library: WPRO
ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive impairment. The main hypotheses about the pathogenesis of AD include the hypothesis of β-amyloid protein, the hypothesis of abnormal phosphorylation of Tau protein, and the hypothesis of neuroinflammation. In recent years, environmental pollutants have been considered as an important factor in causing neurological dysfunction. Common environmental pollutants include heavy metals, pesticides, polychlorinated biphenyls, microplastics, and air pollutants, all of which have been proven to have neurotoxicity. In this review, we not only discussed epidemiological and animal experimental studies that link environmental pollution with AD, but also summarized the mechanisms of action of relevant toxins, providing insights for studying the interrelationships between environmental pollutants and AD.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Plastics / Amyloid beta-Peptides / Neurodegenerative Diseases / Environmental Pollutants / Alzheimer Disease Limits: Animals Language: Zh Journal: Acta Physiologica Sinica Year: 2023 Type: Article
Full text: 1 Index: WPRIM Main subject: Plastics / Amyloid beta-Peptides / Neurodegenerative Diseases / Environmental Pollutants / Alzheimer Disease Limits: Animals Language: Zh Journal: Acta Physiologica Sinica Year: 2023 Type: Article